Researcher's Profile


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Research Outline      2014-03-19 11:09:02

We study nasal NK-cell lymphoma.

I: Past Results:
Our lab has been studying nasal NK-cell lymphoma, an EBV-associated lymphoma of the nasal mucosa. We showed that:
1. Diagnostic criteria: A restricted killer immunoglobulin receptor repertoire is diagnostic of nasal NK-cell lymphoma. (Am J Path, 2001),
2. Prognostic factor: CD94 as a good prognostic factor (Blood, 2003),
3. Cellular Origin: Expression of CD941A in immature NK-cell lymphoma, and CD941B in mature NK cell lymphoma (Blood, 2005).

II: Recent Progress
The molecular mechanisms underlying the above observations have been elusive for years, until recently, we demonstrate that
1. Pathology: There are two subtypes of nasal lymphoma: noninvasive and invasive (HistoPath, 2012),
2. Molecular mechanism: The EBV-encoded miR-BART20-5p inhibits T-bet and IFNg with secondary suppression of p53 in invasive nasal NK-cell lymphoma (Am J Path, 2013, and 2014).