MING-TSUNG TSENG (曾明宗)ORCID Follow
|Profile 2015-11-19 14:48:10|
1.2004~2010: Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan, R.O.C.
2.1992~1999: Department of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
|Career and Experience||
2014 - Assistant Professor, Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C.
1.2011 - 2013 Postdoctoral research fellow in the Pain Imaging Neuroscience Group, Nuffield Department of Clinical Neurosciences and FMRIB Center, University of Oxford, Oxford, U.K.
2.2004 - 2011 Attending neurologist at Far Eastern Memorial Hospital, Taipei, Taiwan, with neurology clinic service at National Taiwan University Hospital, Taipei, Taiwan, R.O.C.
3.2000 - 2004 Neurology residency training at the Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan, R.O.C.
|Research field||Pain in nervous system, functional MRI|
Research Outline 2014-10-16 16:21:42My lab focuses on how humans percept somatosensory stimuli, with a special interest in pain. Using neuroimaging (MRI) complemented by electrophysiological and histopathological techniques, we investigate the neural mechanisms of physiological and pathological pain along the whole neural axis. We are interested in the distinctive neural signature of pain. Given the neural substrates for the cognitive aspects of pain as well as the role of emotion are unclear, we also work to reveal the mechanisms by which humans memorize pain and emotion influences pain processing.
Memory of pain and the effects of emotion
Human responses to pain are shaped by individual autobiographical experiences, and the mnemonic process of pain has been postulated to underpin chronic pain. Nevertheless, current understanding of memory is mainly based on experiments using verbal or visual stimuli, and the neural correlates for the mnemonic processing of pain are largely unknown. Our preliminary data showed a distinct cerebral network that provided temporary storage of pain memory trace, as compared to the retaining of a painless stimulus. In terms of emotion, how we react to an ongoing pain stimulus is affected by our emotional states, which can guide our behaviors for higher cognitive functions, such as planning and decision making. As such, we investigate why subjects with anxiety or depression are more sensitive to pain, and why people suffering from affective disorders are prone to chronic pain. Our preliminary results suggested that anxiety states modulated pain processing via the coupling of neural activity in pain-related brain regions. Our long-term goal is to gain insights into the cognitive aspects of pain as well as the influence of emotion, providing a neural basis on how our brain manipulates the complex nature of a painful stimulus.
Neural mechanisms of chronic pain
Although physiological pain motivates people to avoid the danger, chronic pain causes suffering and destroys quality of life. Neuropathic pain remains a therapeutic challenge and a misery sequel of many neurologic disorders, such as diabetes, herpes zoster, and stroke. A main feature of neuropathic pain is its diverse manifestations, including spontaneous pain, stimulus-evoked pain, and unpleasant abnormal sensation. Evidence from animal studies suggested that maladaptive responses of the brain play key roles in chronic pain, but the neural basis is largely unknown in humans. We start to reveal underpinning mechanisms and categorize these sensory features, with a long-term aim to disentangle pathomechanisms for the development and maintenance of chronic pain. The preliminary observation suggested a unique connectivity pattern of pain-processing areas in subjects with chronic pain. Research results would explain why only some but not all patients having nerve injuries manifest painful symptoms and provide a basis for drug development and monitoring of therapeutic effects of chronic pain in the future.
Publications 16 2017-11-22 13:37:00
Ordered by publish date
- Biomarkers of neuropathic pain in skin nerve degeneration neuropathy: Contact heat-evoked potentials as a physiological signature Pain 2017 | journal-article vol.158,no.3,page.516-525 Scopus: 1 Web of Science: 1 Impact Factor: 5.445
- Determining the neural substrate for encoding a memory of human pain and the influence of anxiety. The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 -Nov | journal-article Scopus: 0 Web of Science: 0 Impact Factor: 5.988
- Pain in early-stage Parkinson's disease: Implications from clinical features to pathophysiology mechanisms Journal of the Formosan Medical Association 2017 | journal-article vol.116,no.8,page.571-581 Scopus: 0 Web of Science: 0 Impact Factor: 1.969
- Vigilance-related attention systems subserve the discrimination of relative intensity differences between painful stimuli. Pain 2017 -Oct | journal-article
- Brain imaging signatures of the relationship between epidermal nerve fibers and heat pain perception NeuroImage 2015 | journal-article vol.122,page.288-297 Scopus: 2 Web of Science: 1 Impact Factor: 5.835
- Imaging signatures of altered brain responses in small-fiber neuropathy: Reduced functional connectivity of the limbic system after peripheral nerve degeneration Pain 2015 | journal-article vol.156,no.5,page.904-916 Scopus: 4 Web of Science: 4 Impact Factor: 5.445
- Progress in the treatment of small fiber peripheral neuropathy Expert Review of Neurotherapeutics 2015 | journal-article vol.15,no.3,page.305-313 Scopus: 5 Web of Science: 2 Impact Factor: 3.149
- Effect of aging on the cerebral processing of thermal pain in the human brain Pain 2013 | journal-article vol.154,no.10,page.2120-2129 Scopus: 10 Web of Science: 10 Impact Factor: 5.445
- fMRI evidence of degeneration-induced neuropathic pain in diabetes: Enhanced limbic and striatal activations Human Brain Mapping 2013 | journal-article vol.34,no.10,page.2733-2746 Scopus: 21 Web of Science: 16 Impact Factor: 4.53
- Skin denervation and its clinical significance in late-stage chronic kidney disease Archives of Neurology 2011 | journal-article vol.68,no.2,page.200-206 Scopus: 9 Web of Science: 7 Impact Factor: 2017 N/A
- Distinct and shared cerebral activations in processing innocuous versus noxious contact heat revealed by functional magnetic resonance imaging Human Brain Mapping 2010 | journal-article vol.31,no.5,page.743-757 Scopus: 31 Web of Science: 26 Impact Factor: 4.53
- Pathophysiology of neuropathic pain in type 2 diabetes: Skin denervation and contact heat-evoked potentials Diabetes Care 2010 | journal-article vol.33,no.12,page.2654-2659 Scopus: 33 Web of Science: 31 Impact Factor: 11.857
- Patterns of contact heat evoked potentials (CHEP) in neuropathy with skin denervation: Correlation of CHEP amplitude with intraepidermal nerve fiber density Clinical Neurophysiology 2008 | journal-article vol.119,no.3,page.653-661 Scopus: 56 Web of Science: 48 Impact Factor: 3.866
- Effects of aging on contact heat-evoked potentials: The physiological assessment of thermal perception Muscle and Nerve 2007 | journal-article vol.36,no.1,page.30-38 Scopus: 36 Web of Science: 37 Impact Factor: 2.605
- Skin denervation and cutaneous vasculitis in systemic lupus erythematosus Brain 2006 | journal-article vol.129,no.4,page.977-985 Scopus: 34 Web of Science: 27 Impact Factor: 10.292
- Peripheral nerve disease in SARS: Report of a case Neurology 2003 | journal-article vol.61,no.12,page.1820-1821