Researcher's Profile


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Research Outline      2014-10-01 23:55:36

Research in our lab is centered around the molecular basis of genome dynamics and stress response in cancer and aging by systematically identifying both enzymatic and structural components involved in the chromosome dynamics, stress response and aging pathways, and characterizing how these proteins work. Genomic instability is the leading cause for disease and telomere maintenance is a required step for cancer and aging. We take advantage of the genetically tractable model organisms yeast Saccharomyces cerevisiae and Schizosaccharomyces pombe to approach these questions and use our findings in yeast to extend our studies in mammalian cells, since the fundamental mechanisms of these pathways are preserved from yeast to human.