Researcher's Profile

JANE CHUNG-CHEN YAO (姚宗珍)

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Research Outline      2014-11-04 13:11:09

1.Tissue and cellular reaction to mechanical stimulation
(1)Distraction Osteogenesis:
Most of orthodontic patients require only dental movements to correct their malocclusion. However, severe sagittal jaw discrepancy found in some patients with craniofacial anomalies has to rely on orthognathic surgery to correct this jaw size problem. Recently, distraction osteogenesis has become a choice to treat patients with severe skeletal discrepancy for better stability with larger degree of advancement. However, we know little of mechanisms of soft tissue response following distraction osteogenesis besides bone can grow in the osteotomy sites in head region. Therefore, the adjacent soft tissues especially facial muscles would affect the extent and stability of mandibular distraction osteogenesis. In this study, miniature pigs are used as an animal model to study facial muscles with two different fiber orientations following mandibular distraction. Our ultimate goal is to develop ways to augment soft tissues besides bone structures with mechanical stimulation from distraction osteogenesis.
(2)Cellular response to force stimulation:
Cellular response to force is essential for tooth movement which involves bone resorption, bone deposition and sometimes unwanted root resorption that may or may not repaired with cellular cementum. Therefore, we would like to characterize cells mediating root resorption and signals and changes of cells induced by different mechanical stimulation. The specific aims are as follows: 1) Build up mouse model. 2) Identification cell origin for root resorption. 3) Response of PDL and bone cells at compression side vs. tension side. Our long-term goal is to apply this knowledge to treatment for speeding up the rate of orthodontic tooth movement without damages to the roots.
2.Stability of temporary anchorage devices (TADs)
Animal studies are used to explore the parameters that influence stability of TADs and the consequences of contacting the root and the repairing mechanism.